Synthesis of paclitaxel-C3'-14C

DOI: 10.1002/jlcr.2580360512

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 479 - 492 (1995)

Update date:2022-08-03

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Authors:

Walker Walker

Standridge

Swigor Swigor

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Article abstract of DOI:10.1002/jlcr.2580360512

Reductive cleavage of the C13 side chain of paclitaxel (3) followed by regioselective silylation gave 7-triethylsilylbaccatin III (6). Successive reaction of L-threonine methyl ester hydrochloride (7) with tert-butoxydiphenylchlorosilane, benzaldehyde-C7-

Full text of DOI:10.1002/jlcr.2580360512

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