The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin v

Article abstract of DOI:10.1039/c4md00409d

N-Methylation of the N-Cα peptide bond is a known strategy to overcome the liabilities inherently associated with peptide-like molecules. Here, we apply this strategy to transition state mimetics that are potent inhibitors of the malarial protease, plasme