Structure-activity relationships of the 7-substituents of 5,4-'diamino- 6,8,3'-trifluoroflavone, a potent antitumor agent

Article abstract of DOI:10.1021/jm970728z

Recently, we reported that 5,4'-diamino-6,8,3'-trifluoroflavone (1b) exhibits potent antitumor activity against certain types of human cancer cell lines both in vitro and in vivo. Since the antiproliferative activity of 5,4'-diaminoflavon (1a), the lead c