Journal of Organic Chemistry p. 4542 - 4548 (1995)
Update date:2022-08-04
Topics:
Patterson, John W.
Mycophenolic acid (1) has been synthesized from 2,4-dihydroxybenzoic acid by regioselective introduction of the three required carbon substituents.A key transformation in this sequence is the introduction of the methyl substituent at position 5 by a rapid, uncatalyzed replacement of the bromide in 8 at low temperature by methyllithium.The scope and mechanism of this methylation reaction are examined.
View MoreContact:86 21 3772 9386
Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China
JIANGXI XINXIN CHEMICAL CO., LTD.
Contact:86-15957176628
Address:INDUSTRY ROAD 1, INDUSTRIAL PARK, HEKOU TOWN,YANSHAN COUNTY, JIANGXI PROVINCE, CHINA
JIAXING SUNS INTERNATIONAL TRADE CO LTD
Contact:18367306858
Address:No.123,Huixin Avenue,Huimin Dist
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Nanjing Ruizhi Industry & Technologh Co.，Ltd.
Contact:+86-25-86808110
Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Doi:10.7164/antibiotics.29.890
(1976)Doi:10.1016/j.jorganchem.2013.07.025
(2013)Doi:10.1021/jo8019797
(2008)Doi:10.1021/jm034167p
(2003)Doi:10.1055/s-1976-24146
(1976)Doi:10.1246/bcsj.49.2590
(1976)
