2'-O-aminopropyl ribonucleotides: A zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides

DOI: 10.1021/jm950937o

Source and publish data:

Journal of Medicinal Chemistry p. 5100 - 5109 (1996)

Update date:2022-08-04

Topics:

Authors:

Griffey Griffey

Monia Monia

Cummins Cummins

Freier Freier

Greig Greig

Guinosso

Lesnik Lesnik

Manalili

Mohan Mohan

Owens Owens

Ross Ross

Sasmor Sasmor

Wancewicz

Weiler Weiler

Wheeler Wheeler

Cook Cook

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Article abstract of DOI:10.1021/jm950937o

Oligonucleotides containing 2'-O-aminopropyl-substituted RNA have been synthesized. The 2'-O-(aminopropyl)adenosine (APA), 2'-O- (aminopropyl)cytidine (APC), 2'-O-(aminopropyl)-guanosine (APG), and 2'-O- (aminopropyl)uridine (APU) have been prepared in hi

Full text of DOI:10.1021/jm950937o

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