Preparation of a semisynthetic analogue of mevinolin and compactin

DOI: 10.1021/jo00122a037

Source and publish data:

Journal of Organic Chemistry p. 5532 - 5536 (1995)

Update date:2022-08-04

Topics:

Authors:

Clive Clive

Wickens Wickens

Da Silva

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Article abstract of DOI:10.1021/jo00122a037

Enone 5, derived by chemical degradation of compactin (1), was elaborated into the semisynthetic analogue 4, which is an inhibitor of cholesterol biosynthesis in rat liver microsomes.

Full text of DOI:10.1021/jo00122a037

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