Synthesis of Di- and Triphosphate Ester Analogs via a Modified Michaelis-Arbuzov Reaction

Article abstract of DOI:10.1016/00404-0399(50)10097-

For the first time, benzyl phosphites allowed the preparation of a set of polyphosphonates from chloromethyl halides via the Michaelis-Arbuzov reaction performed under vacuum.Regioselective mono-deprotection or complete deprotection of these phosphonates provide useful building blocks for the synthesis of biological phosphate analogs.