Synthesis of Di- and Triphosphate Ester Analogs via a Modified Michaelis-Arbuzov Reaction

DOI: 10.1016/00404-0399(50)10097-

Source and publish data:

Tetrahedron Letters p. 5183 - 5186 (1995)

Update date:2022-08-05

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Authors:

Saady, Mourad

Lebeau, Luc

Mioskowski, Charles

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Article abstract of DOI:10.1016/00404-0399(50)10097-

For the first time, benzyl phosphites allowed the preparation of a set of polyphosphonates from chloromethyl halides via the Michaelis-Arbuzov reaction performed under vacuum.Regioselective mono-deprotection or complete deprotection of these phosphonates provide useful building blocks for the synthesis of biological phosphate analogs.

Full text of DOI:10.1016/00404-0399(50)10097-

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