Stereoisomers of N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide: Synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics

DOI: 10.1021/jm00018a026

Source and publish data:

Journal of Medicinal Chemistry p. 3652 - 3659 (1995)

Update date:2022-08-04

Topics:

Authors:

Wang Wang

Zhu Zhu

Jin Jin

Chen Chen

Chi Chi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00018a026

N-[1-(2-Hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide (ohmefentanyl, 1) is an extremely potent analgesic agent with high affinity and selectivity for opioid μ receptors. There are three chiral carbons in 1, so eight optically active iso

Full text of DOI:10.1021/jm00018a026

Products guided by the article

Product name:(3S,4S,2'R)-trans-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

Cas No:166768-14-5

R&D Labs maybe for 166768-14-5

Weinan Rigel Pharm Co., Ltd.

Contact:+86-913-2223392

Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
Shanghai Yanchu chemicals Co., Ltd

website:http://www.yanchuchem.com

Contact:0086 18601657701

Address:Room 1292, Building NO. 2, Lane 65, Huandong 1st Rd, Fengjing Town, Jinshan Distriction, shanghai
Zibo Ocean International Trade Co.,Ltd(expird)

Contact:+86 533 5160706

Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Sanming Coffer Fine Chemical Industrial Co., Ltd

website:http://www.cofferxm.com/

Contact:+86-598-5853979

Address:Jin-sha Yuan Chuang-ye Park,Hi-Tech Development Zone,Sanming City P.R.China
Nanyang Tianhua pharmaceutical Co.,Ltd.

Contact:+8618639816203

Address:Longsheng Industrial Park

Relevant to this article

1H and 13C NMR Study of Substituted Effects in 2- and 3-Substituted Diphenyl Sulphides and Sulphones and 4-Substituted 2',6'-Dimethyldiphenyl Sulphides

Doi:10.1002/mrc.1260331004
(1995)
Synthesis from pregnenolone of fluorescent cholesterol analogue probes with conjugated unsaturation in the side chain

Doi:10.1021/jo00227a020
(1987)
Novel Photochemical Alkyl Migrations of Dialkylboryl Acetylacetonate Complexes

Doi:10.1021/ja00262a036
(1986)
Phosphinylhydrazyls R2NNP(O)L2, an ESR Study. Influence of the Captodative Effect on the Three-Electron NN ? Bond

Doi:10.1021/jo00353a013
(1986)
Photophysics of 2-Phenyl-3-indolocarbocyanine Dyes

Doi:10.1021/j100278a041
(1986)
NUCLEOPHILIC ATTACK OF AMINE AND HYDROXYDE TO PLATINUM DIBENZONITRILE DICHLORIDE. CRYSTAL STRUCTURE OF (2) AND cis-

Doi:10.1021/ja00266a011
(1986)

Article Doi