Stereoisomers of N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide: Synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics

Article abstract of DOI:10.1021/jm00018a026

N-[1-(2-Hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide (ohmefentanyl, 1) is an extremely potent analgesic agent with high affinity and selectivity for opioid μ receptors. There are three chiral carbons in 1, so eight optically active iso