Stereoisomers of N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide: Synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics

DOI: 10.1021/jm00018a026

Source and publish data:

Journal of Medicinal Chemistry p. 3652 - 3659 (1995)

Update date:2022-08-04

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Authors:

Wang Wang

Zhu Zhu

Jin Jin

Chen Chen

Chi Chi

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Article abstract of DOI:10.1021/jm00018a026

N-[1-(2-Hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide (ohmefentanyl, 1) is an extremely potent analgesic agent with high affinity and selectivity for opioid μ receptors. There are three chiral carbons in 1, so eight optically active iso

Full text of DOI:10.1021/jm00018a026

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