Functional derivatives of 4-oxoazetidine-2-sulfinic acids in asymmetric synthesis of 2-azacepham sulfoxides and their transformation

Article abstract of DOI:10.1016/0040-4020(95)98705-M

The enantiomerically pure 2-azacepham sulfoxide 2a was synthesized by stereocontrolled intramolecular cyclization of sulfinates 3 or sulfinamides 8 in the presence of dry hydrogen chloride followed by triethylamine. The cyclization accrued via equilibrate