A new class of chiral modifiers for the enantioselective hydrogenation of α-ketoesters with Pt/Al2O3

Article abstract of DOI:10.1016/0957-4166(95)00034-M

A series of enantiomerically pure chiral amino alcohols have been synthesized and applied as modifiers in the enantioselective hydrogenation of ethyl pyruvate over supported Pt catalysts. Their use enabled an enantiomeric excess of up to 75%. A molecular modelling study of the modifiers and reactant on a Pt(111) surface provides explanation for the observed enantiodifferentiation.