Welcome to LookChem.com Sign In|Join Free

Article Doi

Synthesis and biological activity of N-(aminoiminomethyl)-1H-indole carboxamide derivatives as Na+/H+ exchanger inhibitors

DOI: 10.1248/cpb.47.1538

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1538 - 1548 (1999)

Update date:2022-07-30

Topics:

Authors:

Kitano, MasafumiKitano, Masafumi

Kojima, AtsuyukiKojima, Atsuyuki

Nakano, KazuhiroNakano, Kazuhiro

Miyagishi, AkiraMiyagishi, Akira

Noguchi, TsuyoshiNoguchi, Tsuyoshi

Ohashi, NaohitoOhashi, Naohito

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.1538

A series of N-(aminoiminomethyl)-1H-indole carboxamide derivatives were synthesized and their inhibitory potencies against the Na+/H+ exchanger were measured. Variation of the carbonylguanidine group at the 2- to 7- position of the indole ring system showed that a substitution at the 2- position improved the Na+/H+ exchanger inhibitory activity the most in vitro. This led to the synthesis and evaluation of an extensive series of N- (aminoiminomethyl)-1H-indole-2-carboxamide derivatives. Derivatives having an alkyl or substituted alkyl group at the 1-position of the indole ring system showed higher levels of in vitro activities. N-(aminoiminomethyl)-1-(2- phenylethyl)-1H-indole-2-carboxamide (49) had the strongest activity.

View More

Full text of DOI:10.1248/cpb.47.1538

NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  

Products guided by the article

Product name:methyl 1-(2-phenylethyl)-1H-indole-2-carboxylate

Cas No:167478-95-7

167478-95-7

R&D Labs maybe for 167478-95-7

Relevant to this article

Hot Product