Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

DOI: 10.1021/acs.jmedchem.7b01845

Source and publish data:

Journal of Medicinal Chemistry p. 1340 - 1354 (2018)

Update date:2022-08-03

Topics: Inhibitors Derivatives Potent Selective Reversible Monoacylglycerol Lipase (MAGL)

Authors:

Aghazadeh Tabrizi, Mojgan

Baraldi, Pier Giovanni

Baraldi, Stefania

Ruggiero, Emanuela

De Stefano, Lucia

Rizzolio, Flavio

Di Cesare Mannelli, Lorenzo

Ghelardini, Carla

Chicca, Andrea

Lapillo, Margherita

Gertsch, Jürg

Manera, Clementina

Macchia, Marco

Martinelli, Adriano

Granchi, Carlotta

Minutolo, Filippo

Tuccinardi, Tiziano

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Article abstract of DOI:10.1021/acs.jmedchem.7b01845

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes. Beyond the possible utilization of MA

Full text of DOI:10.1021/acs.jmedchem.7b01845

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