Michael additions of 3,3-dimethylacrylamides and amines: Synthesis of the growth hormone secretagogue L-692,585

Article abstract of DOI:10.1080/00397919508015901

A highly efficient synthesis of the potent Human Growth Hormone Secretagogue L-692,585 1 via a Micheal addition with a 3,3-dimethyl acrylic acid derivative 7 and (R)-1-amino-2-propanol 2 is presented.

Full text of DOI:10.1080/00397919508015901

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Synthetic Communications: An
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Michael Additions of 3,3-
Dimethylacrylamides and
Amines: Synthesis of the
Growth Hormone Secretagogue
L-692,585
Kenneth M. Wells a , Kai Rossen a , David Askin a ,
Frederick W. Hartner Jr. a , R. P. Volante a & Paul J.
Reider a
a Merck Research Laboratories, Department of
Process Research , P. O. Box 2000, Rahway, NJ,
07065-0900
Published online: 23 Sep 2006.
To cite this article: Kenneth M. Wells , Kai Rossen , David Askin , Frederick
W. Hartner Jr. , R. P. Volante & Paul J. Reider (1995) Michael Additions of
3,3- Dimethylacrylamides and Amines: Synthesis of the Growth Hormone
Secretagogue L-692,585, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 25:14, 2197-2202, DOI:
10.1080/00397919508015901
To link to this article: http://dx.doi.org/10.1080/00397919508015901
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