Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound

Article abstract of DOI:10.1016/0960-894X(96)00163-1

The medicinal chemistry strategy which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date.