Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound

DOI: 10.1016/0960-894X(96)00163-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1015 - 1020 (1996)

Update date:2022-08-04

Topics:

Authors:

Armour Armour

Chung Chung

Congreve

Evans Evans

Guntrip Guntrip

Hubbard Hubbard

Kay Kay

Middlemiss

Mordaunt

Pegg Pegg

Vinader Vinader

Ward Ward

Watson Watson

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Article abstract of DOI:10.1016/0960-894X(96)00163-1

The medicinal chemistry strategy which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date.

Full text of DOI:10.1016/0960-894X(96)00163-1

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