Highly efficient resolution of benzopyrano[4,3-c]isoxazolidine derivatives. Versatile chiral auxiliaries for asymmetric alkylation

Article abstract of DOI:10.1016/0957-4166(95)00162-I

Benzopyrano[4,3-c]isoxazolidine derivatives, newly developed chiral auxiliaries for asymmetric alkylation, were synthesized and resolved in a unique manner. Resolution could be executed so efficiently that both enantiomers were obtained with a single resolving reagent in excellent yields.