Studies in marine macrolide synthesis: Asymmetric synthesis of C1-C15/C16 subunits of swinholide A and scytophycin C

Article abstract of DOI:10.1016/S0040-4039(00)73995-5

The aldehyde 8, a C_1-C₁₅ subunit of swinholide A, was prepared in 10 steps (14.5% yield, 78% ds) by starting with the asymmetric aldol reaction, 15 + 17 → 18. Conversion into the corresponding ethyl ketone 9 provides a C_1-