Novel cytotoxic 3'-(tert-butyl) 3'-dephenyl analogs of paclitaxel and docetaxel

DOI: 10.1021/jm00019a012

Source and publish data:

Journal of Medicinal Chemistry p. 3821 - 3828 (1995)

Update date:2022-08-03

Topics:

Authors:

Ali Ali

Hoemann Hoemann

Aube Aube

Mitacher

Georg Georg

McCall McCall

Jayasinghe

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Article abstract of DOI:10.1021/jm00019a012

3'-(tert-Butyl) 3'-dephenyl analogs of paclitaxel were synthesized from 10-deacetylbaccatin III and oxazolidinecarboxylic acid 7 followed by acylation of intermediate amines 10 and 11. Oxazolidinecarboxylic acid 7 was prepared in five steps and in good ov

Full text of DOI:10.1021/jm00019a012

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Product name:3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

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