Synthesis of quinazoline C-nucleosides: A new class of 6:6 bicyclic purine-like analogues

Article abstract of DOI:10.1080/15257779508012393

The quinazoline C-nucleoside congeners of adenosine (1) and inosine (2) have been obtained by radical-induced addition of 4-bromobutyronitrile to C- ribosyl acrylonitrile 10. A base-catalyzed Ziegler-Thorpe cyclization of the dinitrile thus obtained (11)

Full text of DOI:10.1080/15257779508012393

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Nucleosides and Nucleotides
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Synthesis of Quinazoline C-Nucleosides:
A New Class of 6:6 Bicyclic Purine-Like
Analogues.1
Mallela S. P. Sarma a , Phyllis Wilson a , Brian A. Otter a & Robert S.
Klein a
a Albert Einstein College of Medicine Cancer Center and Medicinal
Chemistry Laboratory, Department of Oncology, Montefiore Medical
Center , Bronx, NY, 10467-2401
Published online: 16 Feb 2007.
To cite this article: Mallela S. P. Sarma , Phyllis Wilson , Brian A. Otter & Robert S. Klein (1995)
Synthesis of Quinazoline C-Nucleosides: A New Class of 6:6 Bicyclic Purine-Like Analogues.1 ,
Nucleosides and Nucleotides, 14:3-5, 397-400
To link to this article: http://dx.doi.org/10.1080/15257779508012393
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