Cardioselective ammonium, phosphonium, and sulfonium analogues of α- tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals

Article abstract of DOI:10.1021/jm00015a010

Analogues of α-tocopherol and ascorbic acid with permanently cationic substituents, i.e., phosphonium (8, 9), sulfonium (11), acylhydrazinium (13, 14), and ammonium (1, 16, 21), were synthesized, and the 2R and 2S enantiomers of the α-tocopherol analogues