Tetrahedron Asymmetry p. 1601 - 1610 (1995)
Update date:2022-08-03
Topics: Reaction Conditions Substrate Design Process Optimization Analytical Methods Scale-Up Considerations
Soloshonok
Fokina
Rybakova
Shishkina
Galushko
Sorochinsky
Kukhar
Savchenko
Svedas
β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs a very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.
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