Biocatalytic approach to enatiomerically pure β-amino acids

DOI: 10.1016/0957-4166(95)00204-3

Source and publish data:

Tetrahedron Asymmetry p. 1601 - 1610 (1995)

Update date:2022-08-03

Topics: Reaction Conditions Substrate Design Process Optimization Analytical Methods Scale-Up Considerations

Authors:

Soloshonok

Fokina Fokina

Rybakova

Shishkina

Galushko

Sorochinsky

Kukhar Kukhar

Savchenko

Svedas Svedas

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Article abstract of DOI:10.1016/0957-4166(95)00204-3

β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs a very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.

Full text of DOI:10.1016/0957-4166(95)00204-3

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Product name:β-(N-phenylacetylamino)-β-(4-methoxyphenyl)propionic acid

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