Rhizoxin synthetic studies. 1. Synthesis of the right hand [C(1) to C(9)]portion via a "pinwheel" approach

Article abstract of DOI:10.1016/0040-4039(95)01193-L

A concise synthetic approach to the C(1) - C(9) fragment of the antitumor macrolide rhizoxin via a three-fold pseudosymmetric intermediate is described. The preparation (from readily available γ-butyrolactone) includes both an asymmetric allylation and an