Synthetic studies toward potent cytotoxic agent amphidinolide B : Synthesis of the entire C14-C26 moiety of the top half

Article abstract of DOI:10.1246/cl.1997.563

Regioselective hydroboration of a 4-methyl-2-alkene, oxidation of the resulting mixture of isomeric alcohols, and finally diastereoselective reduction of the ketone are the key steps in the stereoselective synthesis of C19-C26 fragment of amphidinolide B