Stereoselective Synthesis of N-Acetyl-α-neuraminosyl-galactose Disaccharide

Article abstract of DOI:10.1246/cl.1995.455

The glycosylation of N-acetylneuraminic acid (Neu5Ac) donor having an easily accessible acetoxy or phenoxycarbonyloxy leaving group at an annomeric position with the 6-OH position of D-galactose in propionitrile is effectively promoted by the catalyst generated from dichlorodimethylsilane and silver perchlorate to afford the corresponding α-sialosides in good yield with good stereoselectivity.