Chemical Peptide Bond Formation with α-Trifluoromethyl Substituted α-Amino Acids

DOI: 10.1002/prac.19953370183

Source and publish data:

Journal fur Praktische Chemie - Chemiker-Zeitung p. 391 - 396 (1995)

Update date:2022-08-05

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Authors:

Hollweck, Wolfgang

Burger, Klaus

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Article abstract of DOI:10.1002/prac.19953370183

The reaction of α-trifluoromethyl substituted N-tert-butoxycarbonyl amino acids (Boc-TFM-Xaa-OH) 1 with dicyclohexylcarbodiimide results in formation of 2-tert-butoxy-4-trifluoromethyl-5(4H)-oxazolones 2 within minutes.Compounds 2 react with amino acid es

Full text of DOI:10.1002/prac.19953370183

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