Lipoxygenase inhibitors, IV: Synthesis and cyclization reactions of open-chain N1-aryl-substituted amidrazones

Article abstract of DOI:10.1002/ardp.19953280607

α-Carbonyl carboxylic acid arylhydrazonochlorides obtained by Japp-Klingemann reaction are the starting substances for the synthesis of α-carbonyl carboxylic acid arylhydrazonoamides, -esters and -thioesters. The inhibiting activity of these compounds against 15- and 5-lipoxygenase is described. Reactions of derivatives of amidrazones with formaldehyde give triazole, triazoline and unexpected benzotriazepine derivatives.