Synthesis of spiro[cyclohexane-1,2'-[2H]indene] derivatives as inhibitors of steroid 5α-reductase

Article abstract of DOI:10.1002/hlca.19950780407

The spiro[cyclohexane-1,2'-[2H]indene] derivatives 15a,b with molecular dimensions and nucleophilic functional groups similar to known steroid 5α-reductase inhibitors (e.g. 2) were synthesized. The spiro[cyclohexane-1,2'-[2H]indene]-1'(3'H),4-dione (5) wa