Efficient coupling of amino acid derivatives to rigid organic scaffolds: Model syntheses for de novo proteins

Article abstract of DOI:10.1016/0040-4020(95)00485-Q

We describe the coupling of amino acid derivatives to four different rigid organic macrocycles. The couplings were achieved in high yields, which augurs well for the coupling of polypeptides to the rigid macrocycles to create a new family of de novo prote