Cyclopeptides from Ascidians. Total Synthesis of Lissoclinamide 4, and a General Strategy for the Synthesis of Chiral Thiazoline-containing Macrocyclic Peptides.

Article abstract of DOI:10.1016/0040-4039(95)01166-F

In the first synthesis of a chiral thiazoline-containing macrocyclic peptide, a total synthesis of lissoclinamide 4 2c, produced by the marine tunicate Lissoclinum patella, is described.