Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: Characterization of α- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D- aspartate) receptor and anticonvulsant activ

Article abstract of DOI:10.1021/jm00019a003

Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primarily f