Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: Characterization of α- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D- aspartate) receptor and anticonvulsant activ

DOI: 10.1021/jm00019a003

Source and publish data:

Journal of Medicinal Chemistry p. 3720 - 3740 (1995)

Update date:2022-08-04

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Authors:

Bigge Bigge

Malone Malone

Boxer Boxer

Nelson Nelson

Ortwine Ortwine

Schelkun

Retz Retz

Lescosky

Borosky Borosky

Vartanian

Schwarz Schwarz

Campbell

Robichaud

Watjen Watjen

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Article abstract of DOI:10.1021/jm00019a003

Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primarily f

Full text of DOI:10.1021/jm00019a003

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