Stereospecific synthesis of (R)- and (S)-Baclofen and (R)- and (S)- PCPGABA [4-amino-2-(4-chlorophenyl)butyric acid] via (R)- and (S)-3-(4- chlorophenyl)pyrrolidines

DOI: 10.1248/cpb.43.1302

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1302 - 1306 (1995)

Update date:2022-08-05

Topics:

Authors:

Yoshifuji

Kaname Kaname

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.1302

(R)- and (S)-baclofen and (R)- and (S)-PCPGABA [4-amino-2-(4- chlorophenyl)butyric acid] were stereospecifically synthesized via (R)- and (S)-3-(4-chlorophenyl)pyrrolidines, starting from trans-4-hydroxy-L-proline. The syntheses involve two key operations

Full text of DOI:10.1248/cpb.43.1302

NII-Electronic Library Service

Products guided by the article

Product name:(3S)-1-tert-butoxycarbonyl-3-(4-chlorophenyl)pyrrolidine

Cas No:171897-45-3

R&D Labs maybe for 171897-45-3

FUJIAN SHANSHUI CHEMICAL CORP.LTD.

Contact:+86-151-59920036

Address:Jinqiao Gareden, jo@fj-xinyi.com
Changsha Botaniex Inc.

Contact:(86) 731 88718666

Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
Nanjing Fubang Chemical Co.,Ltd

Contact:+86-25-83179199

Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
jiangsu hualin chemical co.,ltd.

Contact:86-25-87787402

Address:jaingsu,china
Chemieliva Pharmaceutical Co., Ltd.

website:http://www.chemieliva.com

Contact:+86-23-67770219

Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang

Relevant to this article

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Doi:10.1016/j.bmcl.2015.01.024
(2015)
Palladium-catalyzed intermolecular C3 alkenylation of indoles using oxygen as the oxidant

Doi:10.1021/ol302840b
(2012)
Preparation and Characterization of the Triflate Complex [Cp*(dppe)FeOSO2CF3]: A Convenient Access to Labile Five- and Six-Coordinate Iron(I) and Iron(II) Complexes

Doi:10.1002/ejic.201901086
(2020)
Synthesis and amination of 1-alkyl-6-nitro-4-oxo-7-chloro-1,4-dihydroquinoline-3-carboxylic acids

Doi:10.1007/BF02464110
(1997)
Cascade cyclizations of cyclic sulfates: An enantioselective alternative to polyepoxide cyclizations in the synthesis of poly(tetrahydrofurans)

Doi:10.1021/ja00156a031
(1995)
Bulky chelating diamide complexes of zirconium: Synthesis, structure, and reactivity of d⁰ alkyl derivatives

Doi:10.1021/om9703503
(1997)

Article Doi