Stereospecific synthesis of (R)- and (S)-Baclofen and (R)- and (S)- PCPGABA [4-amino-2-(4-chlorophenyl)butyric acid] via (R)- and (S)-3-(4- chlorophenyl)pyrrolidines

DOI: 10.1248/cpb.43.1302

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1302 - 1306 (1995)

Update date:2022-08-05

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Authors:

Yoshifuji

Kaname Kaname

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Article abstract of DOI:10.1248/cpb.43.1302

(R)- and (S)-baclofen and (R)- and (S)-PCPGABA [4-amino-2-(4- chlorophenyl)butyric acid] were stereospecifically synthesized via (R)- and (S)-3-(4-chlorophenyl)pyrrolidines, starting from trans-4-hydroxy-L-proline. The syntheses involve two key operations

Full text of DOI:10.1248/cpb.43.1302

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