Chemistry of Natural Compounds p. 113 - 115 (1993)
Update date:2022-09-26
Topics:
Tolstikov, G. A.
Mustafin, A. G.
Gataullin, R. R.
Abdrakhmanov, I. B.
Plyasunova, A. G.
Pokrovskii, A. G.
2,3-Didehydro-3'-deoxythymidine has been obtained with an overall yield of 10percent by the condensation of 1,2-di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose with bis(dimethylsilyl)thymine and a series of subsequent transformations.The anti-HIV activity of the compound obtained was studied on the model of MT-4 lymphoid cells primarily infected with HIV-1.It was found that the substance effectively inhibits the reproduction of HIV-1 in a cell culture.
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