Helvetica Chimica Acta p. 1423 - 1429 (1994)
Update date:2022-07-30
Topics:
Obrecht
Bohdal
Ruffieux
Muller
Novel, more reliable and general reaction conditions for the α-alkylation of 4-monosubstituted 2-phenyloxazol-5(4H)-ones (= 4-monosubstituted 2-phenyl-azlactones) rac-2 to 4,4-disubstituted 2-phenyloxazol-5(4H)-ones rac-1 were found. Thus, a whole range of highly functionalized rac-1 were prepared in medium-to-good overall yields (40-90%). Azlactones rac-1 are ideal precursors for the synthesis of optically pure α,α-disubstituted (R)- and (S)-α-amino acids.
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Doi:10.1016/0040-4039(95)02008-D
(1995)Doi:10.1039/c7dt00828g
(2017)Doi:10.1016/0040-4020(95)00924-8
(1996)Doi:10.1016/S0040-4020(01)98779-4
(1970)Doi:10.1002/jhet.5570320523
(1995)Doi:10.1016/S0957-4166(03)00177-0
(2003)