Regio- and Enantioselectivity of the Candida antarctica Lipase Catalyzed Amidations of Cbz-L- and Cbz-D-Glutamic Acid Diesters

Article abstract of DOI:10.1016/0957-4166(95)00310-L

Candida antarctica lipase (CAL) catalyzed amidation of Cbz-glutamic acid diesters takes place in a regioselective way to give the corresponding monoamide derivatives.The regioselectivity was found to be dependent on the reacting Glu enantiomer.Thus, amida