N-O diheterocyclic nucleosides: Synthesis of 2'-N-methyl-3'-hydroxymethyl-1',2'-isoxazolidinylthymidine

Article abstract of DOI:10.1016/0040-4039(95)01499-8

Isoxazolidine thymidine derivatives were synthesized by the condensation of silylated thymine with isoxazolidinyl acetate prepared by the Michael addition of an α,β-unsaturated ester with N-methylhydroxyamine followed by DIBAL reduction and acetate produc