Attempted Enantioselective Synthesis of Terbutaline. Unexpected Partial Racemization During Lithium Aluminium Hydride Reduction of a Secondary Amide

DOI: 10.1071/CH9951741

Source and publish data:

Australian Journal of Chemistry p. 1741 - 1746 (1995)

Update date:2022-08-03

Topics:

Authors:

Donohue, Andrew C.

Jackson, W. Roy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1071/CH9951741

Syntheses leading to compounds related to the brobchodilator (-)-terbutaline via optically active cyanohydrins suffered unexpected partial racemization during lithium aluminium hydride reduction of key amide intermediates.

Full text of DOI:10.1071/CH9951741

Products guided by the article

Product name:2-Acetoxy-N-(t-butyl)-2-(3-phenoxyphenyl)acetamide

Cas No:172876-91-4

R&D Labs maybe for 172876-91-4

Henan Techway Chemical Co.,Ltd.

website:http://www.techwaychem.com

Contact:+86-371-66380080

Address:No.27 Shunhe Road,
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China
Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone
Jiangsu Jiuri Chemical Co.,Ltd.

Contact:+86-519-82118868

Address:Tianwang Town, Jurong City, Jiangsu Province, China
SINFACHEM LIMITED

Contact:86-25-84683399

Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002

Relevant to this article

Facile synthesis of 1-(acetic acid)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane: a reactive precursor chelating agent

Doi:10.1016/j.tetlet.2009.03.198
(2009)
Synthesis of novel metal complexes of 2-((phenyl (2-(4-sulfophenyl) hydrazono) methyl) diazenyl) benzoic acid formazan dyes: Characterization, antimicrobial and optical properties studies on leather

Doi:10.1016/j.molstruc.2018.07.081
(2019)
A dimeric sinapaldehyde glucoside from Ilex rotunda

Doi:10.1016/0031-9422(95)00499-8
(1996)
Remarkable effect of 2[small alpha]-modification on the VDR antagonistic activity of 1small alpha-hydroxyvitamin D3-26,23-lactones.

Doi:10.1039/b311107e
(2003)
Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I.

Doi:10.1016/S0960-894X(02)00374-8
(2002)
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.

Doi:10.1021/jm950707+
(1996)

Article Doi