Tetrahedron Letters p. 9401 - 9404 (1995)
Update date:2022-09-26
Topics:
Eduardo, Moya
Blagbrough, Ian S.
Reductive alkylation allows a rapid and practical entry to the polyamine amide wasp toxin philanthotoxin-4.3.3.Philanthotoxin-3.4.3 has been prepared, in two steps, by the monoacylation of sperimine.These polyamine amides are selective molecular pharmacological tools for cation channels gated by glutamic acid and acetylcholine, and may have potential as a neuroprotective agents.
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Doi:10.1021/jm201000j
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