New cyclohexyl-based chiral auxiliaries: Enantioselective synthesis of α-hydroxy acids

DOI: 10.1016/0040-4020(95)00771-Y

Source and publish data:

Tetrahedron p. 12169 - 12178 (1995)

Update date:2022-07-30

Topics:

Authors:

Basavaiah, Deevi

Krishna, Peddinti Rama

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Article abstract of DOI:10.1016/0040-4020(95)00771-Y

(1R,2R)-2-(4-tert-butylphenoxy) cyclohexan-1-ol (5) and (1R,2R)-2-(4-phenylphenoxy) cyclohexan-1-ol (6) have been used for the first time as chiral auxiliaries. Addition of alkylzinc chlorides to the corresponding glyoxylates 5a, 6a, after hydrolysis, provided (R)-α-hydroxy acids in high optical purities.

Full text of DOI:10.1016/0040-4020(95)00771-Y

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