Tetrahedron Letters p. 8387 - 8390 (1995)
Update date:2022-09-26
Topics:
Zhang, Lin-hua
Meier, W.
Wats, E.
Costello, T. D.
Ma, P.
et al.
Traditional syntheses of benzodiazepines involve a Bischler-Napieralski reaction which is a three step process and gives low overall yields.An attractive alternative is to construct the diazepine ring under Pictet-Spengler conditions.This paper reports the synthesis of a novel pyridoindolobenzodiazepine as a potent atypical antipsychotic agent.The key step in the synthesis is the ring formation of the diazepine ring in neat trifluoroacetic acid.
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