Tetrahedron Letters p. 8387 - 8390 (1995)
Update date:2022-09-26
Topics:
Zhang, Lin-hua
Meier, W.
Wats, E.
Costello, T. D.
Ma, P.
et al.
Traditional syntheses of benzodiazepines involve a Bischler-Napieralski reaction which is a three step process and gives low overall yields.An attractive alternative is to construct the diazepine ring under Pictet-Spengler conditions.This paper reports the synthesis of a novel pyridoindolobenzodiazepine as a potent atypical antipsychotic agent.The key step in the synthesis is the ring formation of the diazepine ring in neat trifluoroacetic acid.
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Doi:10.1021/ja01641a001
(1954)Doi:10.1016/0040-4020(96)00034-8
(1996)Doi:10.1021/op700218j
(2008)Doi:10.1016/S0968-0896(98)00148-5
(1998)Doi:10.1135/cccc19961037
(1996)Doi:10.1016/0020-1693(96)05027-X
(1996)
