A practical approach to enantiomerically pure cis-epoxides. Synthesis of (+)-disparlure

Article abstract of DOI:10.1016/0957-4166(95)00405-X

An efficient synthesis of (+)-disparlure has been achieved in > 99.8% ee via the Sharpless asymmetric dihydroxylation followed by Mitsunobu inversion of one hydroxyl group and conversion of the resultant erythro diol to the cis epoxide.