Synthesis and Properties of Mechanism-based Inhibitors and Probes for Inositol Monophosphatase derived from 6-O-(2'-Hydroxyethyl)-(1R,2R,4R,6R)-cyclohexane-1,2,4,6-tetraol

DOI: 10.1039/c39950002353

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 2353 - 2356 (1995)

Update date:2022-08-04

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Authors:

Schulz, Juergen

Wilkie, John

Lightfoot, Philip

Rutherford, Trevor

Gani, David

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Article abstract of DOI:10.1039/c39950002353

The 1-phosphate, 2'-phosphate and 1,2'-cyclic phosphate of 6-O-(2-hydroxyethyl)-cyclohexane-1,2,4,6-tetraol are synthesised and found to be good inhibitors of inositol monophosphatase; the stereochemistry of the most potent inhibitor, the (1R,2R,4R,6R)-1-phosphate, provides useful mechanistic insight into the action of this enzyme, the putative target for lithium therapy.

Full text of DOI:10.1039/c39950002353

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