Synthesis and Properties of Mechanism-based Inhibitors and Probes for Inositol Monophosphatase derived from 6-O-(2'-Hydroxyethyl)-(1R,2R,4R,6R)-cyclohexane-1,2,4,6-tetraol

DOI: 10.1039/c39950002353

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 2353 - 2356 (1995)

Update date:2022-08-04

Topics:

Authors:

Schulz, Juergen

Wilkie, John

Lightfoot, Philip

Rutherford, Trevor

Gani, David

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39950002353

The 1-phosphate, 2'-phosphate and 1,2'-cyclic phosphate of 6-O-(2-hydroxyethyl)-cyclohexane-1,2,4,6-tetraol are synthesised and found to be good inhibitors of inositol monophosphatase; the stereochemistry of the most potent inhibitor, the (1R,2R,4R,6R)-1-phosphate, provides useful mechanistic insight into the action of this enzyme, the putative target for lithium therapy.

Full text of DOI:10.1039/c39950002353

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(+)-(1S,2S,4S,6S)-2,4-Di-O-benzyl-6-O-(2-benzyloxyethyl)cyclohexane-1,2,4,6-tetraol

Cas No:173398-39-5

R&D Labs maybe for 173398-39-5

Ji'an Kexin Trade Co., Ltd.(expird)

Contact:86-0796-8187704 18507063190

Address:ji'an jiangxi
Qingdao Kingway Pharmtech Co., Ltd.

Contact:86-532-87118899

Address:No. 88, Middle Haixi Road, Jiaonan City, Qingdao, China
WENZHOU M&C FOREIGN TRADE CO.,LTD.

Contact:+86-577-88862917

Address:No.8 Liming West Road,Wenzhou,zhejiang,China
Jinhua Haoyuan Chemical CO., LTD(expird)

Contact:86-579-82465583

Address:Jinhua,Zhejiang
jiangsu haian chemical co.,ltd.

Contact:86-513-15851283853

Address:No.99,Changjiang West Road,Haian County,Jiangsu Province,China

Relevant to this article

Convenient synthesis of propane aminophosphonic acids, aminodiphosphonic acids and their structural analogues, mediated by azetidinium salts

Doi:10.1016/S0040-4020(99)00698-5
(1999)
Diastereoselective radical cyclization using a chiral α-methyl-α,β-unsaturated ester: Controlling the stereochemistry at both the α- and β-positions

Doi:10.1016/0957-4166(95)00350-X
(1995)
Efficient Synthesis of O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl)-Ser/Thr Building Blocks for SPPS of O-GlcNAc Glycopeptides

Doi:10.1016/0040-4039(95)01941-A
(1995)
Synthesis of a carboxamide linked U(Br)*U(Br) dimer - Duplex and triplex stabilities of the corresponding oligodeoxynucleotides

Doi:10.1080/15257779508010721
(1995)
Syntheses of deoxy analogues of methyl 3,6-di-O-α-D-mannopyranosyl-α-D-mannopyranoside for studies of the binding site of concanavalin A

Doi:10.1016/0008-6215(95)00268-5
(1995)
Doi:10.2989/16073600309486043
(1951)

Article Doi