Chemical and Pharmaceutical Bulletin p. 1719 - 1723 (1995)
Update date:2022-08-03
Topics:
Seki
Takezaki
Ohuchi
Saitoh
Ishimori
Yasuda
Optical isomers of TZC-1370 (1) were prepared from (R)- and (S)-1-(2- chlorophenoxy)-2,3-epoxypropane. When given intravenously to anesthetized rats, the (S)-isomer was about 40 times more potent in terms of β-blocking activity than the (R)-isomer, while
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