Studies on agents with vasodilator and β-blocking activities. III synthesis and activity of optical isomers of TZC-1370

DOI: 10.1248/cpb.43.1719

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1719 - 1723 (1995)

Update date:2022-08-03

Topics:

Authors:

Seki Seki

Takezaki

Ohuchi Ohuchi

Saitoh Saitoh

Ishimori

Yasuda Yasuda

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Article abstract of DOI:10.1248/cpb.43.1719

Optical isomers of TZC-1370 (1) were prepared from (R)- and (S)-1-(2- chlorophenoxy)-2,3-epoxypropane. When given intravenously to anesthetized rats, the (S)-isomer was about 40 times more potent in terms of β-blocking activity than the (R)-isomer, while

Full text of DOI:10.1248/cpb.43.1719

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