A simple method for N-acylation of adenosine and cytidine nucleosides using carboxylic acids activated in-situ with carbonyldiimidazole

DOI: 10.1016/0040-4039(95)02011-D

Source and publish data:

Tetrahedron Letters p. 9277 - 9280 (1995)

Update date:2022-08-04

Topics:

Authors:

Sinha Sinha

Sinha, Nanda D.

Davis Davis

Davis, Peter

Schultze

Schultze, Lisa M.

Upadhya Upadhya

Upadhya, Krishna

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Article abstract of DOI:10.1016/0040-4039(95)02011-D

Carboxylic acids are activated with 1,1'-carbonyldiimidazole in acetonitrile to form N-acylimidazoles which are then treated with per-trimethylsilyl ethers of nucleosides adenosine or cytidine at ambient temperature to generate exclusively N-acylated-Aden

Full text of DOI:10.1016/0040-4039(95)02011-D

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