Determination of the C-7,9,12,13,17 and 18 stereochemistries of tautomycetin. Synthesis of the tautomycetin degradation product

Article abstract of DOI:10.1016/0040-4039(95)02188-4

Syntheses of the degradation product 3 of tautomycetin (1) and its diastereoisomers have been achieved. Comparison of the spectral data of these diastereoisomers with those of the degradation product of natural 1 indicates that tautomycetin has the 7R,9S,12S,13S,17S,18R stereochemistry.