Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme

DOI: 10.1016/0040-4039(95)02069-1

Source and publish data:

Tetrahedron Letters p. 9 - 12 (1996)

Update date:2022-08-03

Topics:

Authors:

Varaprasad, Chamakura V.

Bulychev, Nickolai

Grollman, Arthur P.

Johnson, Francis

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Article abstract of DOI:10.1016/0040-4039(95)02069-1

A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2′-deoxyguanosine (1) has been synthesized from 2′-deoxyguanosine. The activity of MutY protein toward this and a related oligomer containing 8-methoxy-dG has been studied.

Full text of DOI:10.1016/0040-4039(95)02069-1

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