Stereospecific synthesis of tetradeuterated (R)- and (S)-ifosfamide

Article abstract of DOI:10.1002/(SICI)1099-1344(199602)38:2<105::AID-JLCR821>3.0.CO;2-X

The tetradeuterated analogues of (R)- and (S)-ifosfamide [(S)- and (R)-2-(2-chloro-2,2-dideuterioethyl)amino-3-(2-chloroethyl)-6,6-dideuterio -tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide, (S)- and (R)-1-d₄] were synthesized by modification of a