Gram-scale synthesis of α,α-trehalose 6-monophosphate and α,α- trehalose 6,6'-diphosphate

Article abstract of DOI:10.1016/0008-6215(94)84050-4

α,α-Trehalose derivatives α,α-trehalose 6-monophosphate and α,α-trehalose 6,6′-diphosphate were synthesized to investigate their biological properties of the nonreducing disaccharide. These compounds were significant to the biosynthetic pathway since α,α-trehalose 6-phosphate serves as an intermediate of α,α-trehalose. α,α-Trehalose 6-phosphate was also found to be significant in regulating the first steps of yeast glycolysis. In this paper, a number of methods was described to derive the α,α-trehalose phosphates. Trimethylsilylation and selective methanolysis of primary trimethylsilyloxy group were used.