Synthesis of enantiomerically pure ω-amino acids by asymmetric α-alkylation of chiral ω-aminoalkyloxazolines

Article abstract of DOI:10.1016/0040-4039(95)02205-8

Enantiomerically pure α-alkyl-ω-aminocarboxylic acids 5, 6 and the correspodning α-alkyllactams 7 are synthesized starting from lactams 1 by ring transformation with a chiral aminoalcohol 2, asymmetric α-alkylation of the resulting 2-(ω-aminoalkyl)-oxazolines 3 and final hydrolysis.