Potent inhibitors of neutral endopeptidase. 2-Biphenyl-methylglutaric acid amide derivatives

DOI: 10.1016/0960-894X(95)00551-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 65 - 70 (1996)

Update date:2022-08-04

Topics:

Authors:

Kanno Kanno

Osanai Osanai

Furugohri

Watanabe

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Article abstract of DOI:10.1016/0960-894X(95)00551-4

A series of glutaric acid amide derivatives were synthesized and tested for NEP inhibitory activity. Compounds 14a, 14b, 16a and 22, with a biphenylmethyl group at P'₁ position, showed potent inhibitory activity.

Full text of DOI:10.1016/0960-894X(95)00551-4

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