Ring enlargement reaction of 3-hydroxy-3-propargylisoindolin-1-ones: A new synthetic method for the 2-benzazepine-1,5-diones

Article abstract of DOI:10.1016/0040-4039(95)02184-1

Several 2-benzazepine-1,5-diones were efficiently obtained by treatment of the corresponding N-alkyl-3-hydroxy-3-propargylisoindolin-1-ones with some tentative Lewis acids via intramolecular endo-mode cyclization in the allenyl ketone intermediates genera