Bioorganic and Medicinal Chemistry Letters p. 3183 - 3186 (2002)
Update date:2022-08-04
Topics:
Iwanowicz, Edwin J
Kimball
Lin, James
Lau, Wan F.
Han
Wang, Tammy C.
Roberts, Daniel G.M.
Schumacher
Ogletree, Martin L.
Seiler, Steven M.
A series of retro-binding inhibitors of human α-thrombin was prepared to elucidate structure-activity relationships (SAR) and optimize in vivo performance. Compounds 9 and 11, orally active inhibitors of thrombin catalytic activity, were identified to be efficacious in a thrombin-induced lethality model in mice.
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Doi:10.1002/jsfa.2740181003
(1967)Doi:10.1016/j.bmcl.2013.04.023
(2013)Doi:10.1002/ejoc.201201640
(2013)Doi:10.1039/DT9960000431
(1996)Doi:10.1016/0960-894X(96)00043-1
(1996)Doi:10.1055/s-1996-4162
(1996)